Sladek Research Group | Department of Cell, Molecular, and Systems Biology

Anti-HNF4 alpha Antibody

Welcome to the Sladek Lab

HNF4alpha by Bogan et al.

Welcome to the Sladek Lab

Welcome to the homepage of Dr. Frances M. Sladek.

Dr. Sladek is a Professor of Cell Biology and Toxicologist at the University of California Riverside. She and the members of her lab have been exploring the regulation of tissue-specific gene expression using the mammalian liver as a model.

Much of their work focuses on the transcription factor HNF4, a highly conserved member of the nuclear receptor superfamily that is linked to diabetes and other diseases.

This site provides information about the on going work in the Sladek Lab as well as background information on HNF4 and an on-line tool to predict HNF4 binding sites in any DNA sequence (see HNF4 Motif Finder under Links).

Enjoy!

Computer graphic model of the ligand binding domain of HNF4alpha from Bogan et al., 2000.

Lab News

Frances Sladek, James Borneman, and Poonamjot Deol. (UCR/Stan Lim)

Widely consumed vegetable oil leads to an unhealthy gut

RIVERSIDE, CA - High consumption of soybean oil has been linked to obesity and diabetes and potentially autism, Alzheimer’s disease, anxiety, and depression. Add now to this growing list ulcerative colitis, a form of inflammatory bowel disease, or IBD, characterized...

Frances Sladek

September 02, 2020

Diversifying the sciences

Riverside, CA - Faculty at the University of California, Riverside, have received grants from the University of California-Hispanic Serving Institutions Doctoral Diversity Initiative, or UC-HSI DDI, to increase diversity in the sciences. Khaleel Razak, a professor of psychology, has received...

Frances Sladek

Understanding Why Some People Have Propensity to Disease

RIVERSIDE, CA - Aside from identical twins, no two individuals are completely identical genetically. Most differences between individuals are due to single nucleotide changes or polymorphisms (SNPs) — DNA sequence variations — in the genome. SNPs, the most common type...

Frances Sladek and Karthikeyani Chellappa

February 09, 2012

New Avenue for Treating Colon Cancer

RIVERSIDE, CA - An international research team led by cell biologists at the University of California, Riverside has uncovered a new insight into colon cancer, the third leading cause of cancer-related deaths in the United States. The research provides potential...

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