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We use the whole gamut of modern techniques -- molecular, cellular, biochemical, proteomic, genomic, bioinformatic -- to investigate the role of the transcription factor HNF4 in physiology and disease with particular emphasis on cancer and diabetes. In so doing, we aim to shed light on the molecular mechanisms of tissue-specific gene regulation, the dichotomy between cellular differentiation and proliferation, and the role of transcription regulation and alternative splicing and promoter usage in human evolution.

Current Projects


We gratefully acknowledge past and present funding from a variety of state and federal agencies including the California Breast Cancer Research Coordinating Committee, the UC Toxic Substances Research and Training Grant, the American Heart Association, the National Science Foundation and the National Institutes of Health.

For more information, see Publications and About HNF4.